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Opioidbrukssyndrom (missbruk och beroende) Tolerans och fysiskt och/eller psykologiskt beroende kan utvecklas vid upprepad administrering av opioider som oxikodon.If a CNS depressant or benzodiazepine are needed in a client by now on an opioid analgesic: initiate with a decrease First dose on the benzodiazepine or other CNS depressant; titrate base